Transcriptional reprogramming refers to the process by which gene expression patterns in a cell or organism are altered in response to changes in external or internal signals. This can involve the activation or suppression of specific genes, resulting in changes to the transcriptome and ultimately influencing cellular behavior and function. Transcriptional reprogramming plays a crucial role in various biological processes, such as development, differentiation, and response to environmental stimuli, and is often dysregulated in disease states. Studying transcriptional reprogramming can provide insights into the molecular mechanisms underlying these processes and help identify potential therapeutic targets for various diseases.